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July 21, 2006

Doxorubicin and heart damage

Doxorubicin aka Adriamycin causes heart damage.

According to the University Medical Center at the University
of Groningen in the Netherlands researchers, the damage to
the heart from some cancer drugs is a well known fact but
this is the first long-term study to track the effects of cancer
drugs on the heart that might occur years later.

As a resut of this study, researchers recommend that all
patients treated with drugs known as anthracyclines have
life-long heart function monitoring. They emphasis, even
with the study findings, that doxorubicin is a highly effective
cancer treatment. In addition, today's cancer patients tend
to receive lower doses of these cancer drugs, and
cardioprotective drugs, such as dexrazoxane, were not
available to cancer patients in the past.

Continue reading "Doxorubicin and heart damage" »

December 21, 2005

ZOFRAN for nauseau and vomiting

ZOFRAN is administered to those who feel sick
during two days following chemotherapy.

August 31, 2005

Neulasta and leg pain

(following Neulasta shot fri 1pm)
pain rt leg sat 2-8 pm  2 tylenol
2005 june Sat ~25

NEULASTA

A common adverse effect of chemotherapy, febrile neutropenia can be life-threatening. The FDA has approved Neulasta (pegfilgrastim) to boost production of infection-fighting white blood cells (WBC) in patients with nonmyeloid malignancies who are receiving immunosuppressive anticancer drugs. Administered as a single injection during each chemotherapy cycle, Neulasta has an advantage over Neupogen (filgrastim), the only other drug available for this indication. Neupogen is given daily during chemotherapy.

Although similar to Neupogen, Neulasta has had a polyethylene glycol molecule ("PEG" unit) added to enlarge its filgrastim molecules. This extends the drugs half-life and prolongs its beneficial effects in the body. Drug clearance is regulated by neutrophils, so the drug remains in the blood while the patient needs itwhen he's neutropenic-and clears rapidly when neutrophil levels rise.

In clinical trials, the new drug was well tolerated and safe. The most common adverse reaction was
bone pain, which in most cases responded to nonnarcotic analgesics.

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